Massive Bio Announces Reticulum Nexus - an AI-Driven Multi‑Agent Platform Orchestrating the End-to-end Patient Journey

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BERLIN--(BUSINESS WIRE)--Nov 14, 2025--

ESMO AI & Digital Health 2025 - Massive Bio today introduced Reticulum Nexus, the company’s most significant technological leap to date: a patient-centric, multi-agent platform engineered to coordinate the full oncology journey, from first contact to last-mile enrollment, across networks operating at global scale.

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Reticulum Nexus: Massive Bio’s new AI-driven multi-agent platform supporting every step of the patient journey.

In an environment where clinical trial access has long been constrained by fragmented data pipelines, site-centric processes, and human-heavy workflows, Reticulum Nexus establishes a unified operating fabric. This next-generation system integrates clinical and operational intelligence to match, enroll, and collect outcomes to build more powerful advanced analytics.

The company’s most recent announcements include:

• Full alignment with the CMS Health Tech Ecosystem, reaffirming its mission to modernize clinical trial access through secure, AI-powered patient-facing technology;
• Key partnership with the largest US cancer-patient advocacy group demonstrated the viability of a patient-first operating model; and
• AI prescreening hubs drew recognition from Cancer Moonshot; and partners such as Precision Cancer Consortium scaled deployments across broad and diverse populations.

“Most systems optimize a single node,” said Selin Kurnaz, PhD, Cofounder & CEO. “Reticulum Nexus will help bring in the world’s first scalable patient journey, and paired with the enablement of AI agents.”

“ Moravec’s Paradox shows us the boundary between repetitive and contextual work,” said Arturo Loaiza-Bonilla, MD, Cofounder & Chief Medical AI Officer. “With Reticulum Nexus, multi-agent, contextual AI handles the operational load so clinicians can focus on human care. Dr. Arturo AI already supports thousands of patients; we can now safely scale to millions.”

“Radiant Core is the control plane that makes agentic AI dependable at production scale,” added Çağatay Çulcuoğlu, Cofounder, CTO & COO. “SYNERGYAI OS is the routing fabric connecting every workflow. Together, they deliver interoperability, auditability, and real-world performance from day one.”

Inside Reticulum Nexus

Radiant Core - the control plane focused on data quality, compliance, and agent behavior.

SYNERGYAI OS - the multi-agent operating system

Interoperable Architecture - native FHIR/mCODE integration, governance designed for regulated environments (GDPR, HIPAA).

Modules Available at Launch

• Patient Connect & Clinical Network Apps - Mobile-to-EHR pathways that simplify intake, data flow, and provider workflows.
• Clinical Trial Enabler - Real-time eligibility surfacing with transparent rationales and last-mile enrollment logistics.
• Commercial Intelligence & RWD Explorer - Governed insights for assessing unmet need, feasibility, and real-world outcomes.
• Dr. Arturo AI - Multi-agent patient navigation and clinician support with structured human oversight.

About Massive Bio

Massive Bio, co-founded by Selin Kurnaz, Arturo Loaiza-Bonilla, and Çağatay Çulcuoğlu, transforms the pharmaceutical value chain with AI-driven solutions. As an AI-enabled real-world data company, Massive Bio streamlines patient journeys, improves access to cutting-edge treatments, and optimizes clinical trial operations across 17 countries. A founding member of the CancerX public-private partnership and participant in the White House Cancer Moonshot initiative, the company continues to lead the way in ethical AI and data-driven innovation.

For more information, visit www.massivebio.com.

View source version on businesswire.com:https://www.businesswire.com/news/home/20251112162820/en/

CONTACT: Media Contact:

Mert Turkkan | Marketing Director |[email protected]

KEYWORD: GERMANY EUROPE

INDUSTRY KEYWORD: HEALTH TECHNOLOGY SECURITY DATA MANAGEMENT TECHNOLOGY PHARMACEUTICAL PRACTICE MANAGEMENT APPS/APPLICATIONS ONCOLOGY ARTIFICIAL INTELLIGENCE CLINICAL TRIALS SCIENCE BIOTECHNOLOGY SOFTWARE HEALTH RESEARCH

SOURCE: Massive Bio

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PUB: 11/14/2025 04:12 AM/DISC: 11/14/2025 04:12 AM

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